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The 4th DeLIVER Newsletter

Dear PEARL PIs and nursing leads

 

We are now 91 patients recruited towards our 3000 patient target, which is good going (since we started end of Feb) — though a way to go yet.

Below is the latest “data” extracted from the PEARL bioanalysis portal today and an updated on site set up and recruitment. As expected, alcoholic liver disease and NAFLD are still leading the charge, with HCV, HBV and haemochromatosis following up.

 

A huge thanks to those who attended or dialled in for the face-to-face meeting last week and for all the hard work that went into organising this (Francoise, Sophie, Jenni, Hayley) and chairing sessions (Tim, Aileen). It was a really good day with patient representation, CRUK attending, and some good science and plans presented - but mostly it was just really good to meet everyone. So good that we will repeat this later in the year or early 2023.

Some of the science highlights for me were new metabolomic data, an HCC analysis from the primary care Q research data base, the latest GALAD data from Roche, and a fresh take on HBV described as a “carcinogen”.

 

We have had really positive feedback regarding ease of use of the REDCAP data entry registry, but as ever we (James!) remain on standby to make the study as easy as possible to recruit to, and welcome feedback in real time of any issues regarding the study protocol, blood sampling or shipment of samples. Andy has managed to automate the data inputted to calculate some of the HCC risk scores. Klaudia in the lab here is doing a super job of processing the samples ready for cfDNA analysis as these come in real time. Surprisingly the deficits in sampling appear to be urine and Jenni will be in touch about this.

 

Have a lovely weekend -and do enjoy the sun (being UK it may not last)

 

PEARL recruitment 4

 

Aetiology 4

 

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

No. Patients Recruited

Oxford

Emma Culver

Fully Executed

Yes

Performed

Yes

23/02/2022

25

Hull

Lynsey Corless

Fully Executed

Yes

Performed

Yes

24/03/2022

7

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

13/04/2022

12

St George's

Dan Forton

Fully Executed

Yes

Performed

Yes

26/04/2022

7

Kings

Kosh Agarwal

Fully Executed

Yes

Performed

Yes

29/04/2022

6

Bradford

Sulleman Moreea

Fully Executed

Yes

Performed

Yes

11/05/2022

7

C&W

Matthew Foxton

Fully Executed

Yes

Performed

Yes

11/05/2022

11

Brighton

Sumita Verma

Fully Executed

Yes

Performed

Yes

13/05/2022

2

Middlesbrough

Darren Craig

Fully Executed

Yes

Performed

Yes

26/05/2022

4

Imperial

Nowlan Selvapatt

Fully Executed

Yes

Performed

Yes

30/05/2022

2

Leeds

Ian Rowe

Fully Executed

Yes

Performed

Yes

06/06/2020

2

Wycombe

James Maggs

Fully Executed

Yes

Performed

Yes

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Yes

County Durham & Darlington

Francisco Porras Perez

Fully Executed

Yes

Performed

Yes

Cornwall

Hannah Osborn

Fully Executed

Yes

Performed

Nottingham

Aloysious Aravinthan

Fully Executed

Yes

Performed

Yes

Basingstoke

Kamran Ala

Fully Executed

Yes

Performed

East Kent

Jayshri Shah

Fully Executed

Yes

Booked

Portsmouth

Richard Aspinall

Awaiting Site Signature

Performed

Bristol

- Weston

PI James Orr

Sub-I Andrew Bell

Fully Executed

Yes

Booked

Arranging

Liverpool

Tim Cross

With local R&D

Arranging

Aintree

Nick Stern

With local R&D

Arranging

Sheffield

Laura Harrison

With local R&D

Royal London

Janet Dearden

With local R&D

Royal Free

Aileen Marshall

With local R&D

Birmingham

Tahir Shah

With local R&D

Guys and St Thomas'

Bo Wang

With local R&D

Southampton

Mark Wright

With local R&D

Bournemouth

Safa Al-Shamma

With local R&D

Derby

Andrew Austin

TBD

Gloucester

Coral Hollywood

TBD

Leicester

Ka-Kit Li

TBD

Newcastle

Stuart McPherson

TBD

Manchester

?Martin Prince

TBD

Cambridge

Mike Allison

TBD

Basildon

TBD

Royal Devon

TBD

Whittington Health

TBD

Total Patients Recruited

85

Best Wishes,

Ellie, Will, Jenni, Andy and James