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The 8th DeLIVER Newsletter

Dear study teams,

 

As the days lengthen and the daffodils are blooming, we wanted to send an early spring update re the PEARL and SELINA studies in the CRUK funded DeLIVER program.

We attach some graphs and tables below re recruitment to PEARL and SELINA - I know most of us like data and graphs (and some healthy competition - no names) and I hope you enjoy these - do scroll down.

A huge thanks for the sustained effort in recruitment from most sites. In this newsletter we wanted to give a shout to Hull and Leeds who received the most recent hampers for top recruitment (picture from Leeds - thank you)

Hamper 8

A call out also to Royal Devon who recently recruited our 700th PEARL patient (now at 747) and have surpassed their target recruitment in only 7 weeks since they started recruitment (now at 22 patients). SELINA also making steady progress, now at 40 patients.

 

We’ve had a number of sites enquiring about sending their stored samples to Oxford. We are working on increasing the -80 freezer storage capacity in Oxford and hope to be able to begin shipments in the very near future. In the meantime, you may wish to begin completing the sample manifest. This will need to be completed ahead of any shipments being arranged. Please note, there are 2 worksheets and the ‘Sample List’ worksheet should be completed one row per sample. Please contact Jenni or Emily if you have any further questions on this. We believe that the cfDNA tubes that you have been sending and we have been spinning down real time will be a fantastic resource for scientific analysis and HCC EDx, and this will be complemented by additional biomarkers that can be assessed in the serum/plasma.

We’ll be sending out more cfDNA and Li-Hep tubes over the coming weeks to replace those expiring shortly. The cfDNA tubes are expensive, so any extra effort you can make to push recruitment before they expire would be really appreciated.

 

PEARL

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

No. Patients Recruited

Oxford

Emma Culver

Fully Executed

Yes

Performed

Yes

23/02/2022

78

Hull

Lynsey Corless

Fully Executed

Yes

Performed

Yes

24/03/2022

38

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

13/04/2022

62

St George's

Dan Forton

Fully Executed

Yes

Performed

Yes

26/04/2022

27

Kings

Kosh Agarwal

Fully Executed

Yes

Performed

Yes

29/04/2022

55

Bradford

Sulleman Moreea

Fully Executed

Yes

Performed

Yes

11/05/2022

16

C&W

- West Middlesex

Matthew Foxton

Fully Executed

Yes

Performed

Yes

11/05/2022

20/09/2022

39

6

Brighton

Sumita Verma

Fully Executed

Yes

Performed

Yes

13/05/2022

8

Middlesbrough

Darren Craig

Fully Executed

Yes

Performed

Yes

26/05/2022

58

Imperial

Nowlan Selvapatt

Fully Executed

Yes

Performed

Yes

30/05/2022

27

Leeds

Ian Rowe

Fully Executed

Yes

Performed

Yes

06/06/2022

30

Nottingham

Aloysious Aravinthan

Fully Executed

Yes

Performed

Yes

07/07/2022

38

Wycombe

James Maggs

Fully Executed

Yes

Performed

Yes

11/07/2022

9

Basingstoke

Kamran Ala

Fully Executed

Yes

Performed

Yes

21/07/2022

4

Liverpool

Tim Cross

Fully Executed

Yes

Performed

Yes

22/07/2022

31

Portsmouth

Richard Aspinall

Fully Executed

Yes

Performed

Yes

28/07/2022

32

Co. Durham & Darlington

Francisco Porras Perez

Fully Executed

Yes

Performed

Yes

01/08/2022

13

Aintree

Nick Stern

Fully Executed

Yes

Performed

Yes

16/08/2022

68

Bristol

- Weston

PI Gau Appanna

Sub-I Andrew Bell

Fully Executed

Yes

Performed 

Yes

06/09/2022

15/11/2022

14

Bournemouth

Safa Al-Shamma

Fully Executed

Yes

Performed

Yes

12/09/2022

16

Royal Free

Aileen Marshall

Fully Executed

Yes

Performed

Yes

14/09/2022

9

Southampton

Mark Wright

Fully Executed

Yes

Performed

Yes

22/09/2022

24

Birmingham

Tahir Shah

Fully Executed

Yes

Performed

Yes

10/10/2022

7

East Kent

Christopher Fox

Fully Executed

Yes

Performed

Yes

13/10/2022

9

Cornwall

Fiona Hammonds

Fully Executed

Yes

Performed

Yes

07/12/2022

11

Guys and St Thomas'

Bo Wang

Fully Executed

Yes

Performed

Yes

12/12/2022

6

Royal Devon

Christina Levick

Fully Executed

Yes

Performed

Yes

17/01/2023

23

Derby

- Burton

Andrew Austin

Fully Executed

Yes

Performed

Yes

 

03/02/2023

 

2

Royal London

Janet Dearden

Fully Executed

Yes

Performed

Yes

20/02/2023

5

Manchester

Martin Prince

Fully Executed

Yes

Performed

Yes

01/03/2023

2

Gloucester

Coral Hollywood

Fully Executed

Yes

Performed

Yes

 

 

Leicester

Ka-Kit Li

Fully Executed

Yes

Performed

Yes

 

 

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Yes

 

 

Newcastle

Stuart McPherson

Fully Executed

Yes

Performed

 

 

 

Sheffield

Laura Harrison (Barbara Hoeroldt)

With local R&D

 

 

 

 

 

Cambridge

Mike Allison

TBD

 

Total Patients Recruited

 

 

 

 

 

 

767

PEARL recruitment 8

 

 

SELINA

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

No. Patients Recruited

Oxford

Emma Culver

Fully Executed

Yes

Performed

Yes

23/05/2022

16

Leeds

Ian Rowe

Fully Executed

Yes

Performed

Yes

27/07/2022

7

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

16/08/2022

4

Royal Free

Aileen Marshall

Fully Executed

Yes

Performed

Yes

03/10/2022

4

Birmingham

Tahir Shah

Fully Executed

Yes

Performed

Yes

16/11/2022

3

Nottingham

Guru Aithal

Fully Executed

Yes

Performed

Yes

30/11/2022

1

Liverpool

Tim Cross

Fully Executed

Yes

Performed

Yes

13/12/2022

2

Royal Devon

Christina Levick

Fully Executed

Yes

Performed

Yes

01/02/2023

2

Aintree

Nick Stern

Fully Executed

Yes

Performed

Yes

22/02/2023

1

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Yes

 

 

Bournemouth

Jo Tod

Fully Executed

Yes

Performed

Yes

 

 

Southampton

Janisha Patel

Fully Executed

Yes

Performed

Yes

 

 

Royal London

Janet Dearden

Fully Executed

Yes

Performed

 

 

 

Newcastle

Helen Reeves

Fully Executed

Yes

Performed

 

 

 

St George's

Dan Forton

With local R&D

 

 

 

 

 

Cambridge

 

With local R&D

 

 

 

 

 

Total Patients Recruited

 

 

 

 

 

 

40

 

 SELINA recruitment 8

 

Many thanks to all,

Ellie, Will, Jennie (study coordinator PEARL), Emily (study coordinator SELINA), Andy (Data lead) and James (All things DeLIVER REDCap).

 

(P.S. please do follow us on twitter:  https://twitter.com/DeLIVER_HCC  currently led by Rodrigo - do contact him directly for any site comms you would like us to tweet).

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