Dear PEARL PIs and nursing leads
We are now 91 patients recruited towards our 3000 patient target, which is good going (since we started end of Feb) — though a way to go yet.
Below is the latest “data” extracted from the PEARL bioanalysis portal today and an updated on site set up and recruitment. As expected, alcoholic liver disease and NAFLD are still leading the charge, with HCV, HBV and haemochromatosis following up.
A huge thanks to those who attended or dialled in for the face-to-face meeting last week and for all the hard work that went into organising this (Francoise, Sophie, Jenni, Hayley) and chairing sessions (Tim, Aileen). It was a really good day with patient representation, CRUK attending, and some good science and plans presented - but mostly it was just really good to meet everyone. So good that we will repeat this later in the year or early 2023.
Some of the science highlights for me were new metabolomic data, an HCC analysis from the primary care Q research data base, the latest GALAD data from Roche, and a fresh take on HBV described as a “carcinogen”.
We have had really positive feedback regarding ease of use of the REDCAP data entry registry, but as ever we (James!) remain on standby to make the study as easy as possible to recruit to, and welcome feedback in real time of any issues regarding the study protocol, blood sampling or shipment of samples. Andy has managed to automate the data inputted to calculate some of the HCC risk scores. Klaudia in the lab here is doing a super job of processing the samples ready for cfDNA analysis as these come in real time. Surprisingly the deficits in sampling appear to be urine and Jenni will be in touch about this.
Have a lovely weekend -and do enjoy the sun (being UK it may not last)
|
Site |
PI |
mNCA Status |
C&C Approved |
SIV |
Green Light Issued |
First Patient Recruited |
No. Patients Recruited |
|
Oxford |
Emma Culver |
Fully Executed |
Yes |
Performed |
Yes |
23/02/2022 |
25 |
|
Hull |
Lynsey Corless |
Fully Executed |
Yes |
Performed |
Yes |
24/03/2022 |
7 |
|
Plymouth |
Matthew Cramp |
Fully Executed |
Yes |
Performed |
Yes |
13/04/2022 |
12 |
|
St George's |
Dan Forton |
Fully Executed |
Yes |
Performed |
Yes |
26/04/2022 |
7 |
|
Kings |
Kosh Agarwal |
Fully Executed |
Yes |
Performed |
Yes |
29/04/2022 |
6 |
|
Bradford |
Sulleman Moreea |
Fully Executed |
Yes |
Performed |
Yes |
11/05/2022 |
7 |
|
C&W |
Matthew Foxton |
Fully Executed |
Yes |
Performed |
Yes |
11/05/2022 |
11 |
|
Brighton |
Sumita Verma |
Fully Executed |
Yes |
Performed |
Yes |
13/05/2022 |
2 |
|
Middlesbrough |
Darren Craig |
Fully Executed |
Yes |
Performed |
Yes |
26/05/2022 |
4 |
|
Imperial |
Nowlan Selvapatt |
Fully Executed |
Yes |
Performed |
Yes |
30/05/2022 |
2 |
|
Leeds |
Ian Rowe |
Fully Executed |
Yes |
Performed |
Yes |
06/06/2020 |
2 |
|
Wycombe |
James Maggs |
Fully Executed |
Yes |
Performed |
Yes |
||
|
NNUH |
Simon Rushbrook |
Fully Executed |
Yes |
Performed |
Yes |
||
|
County Durham & Darlington |
Francisco Porras Perez |
Fully Executed |
Yes |
Performed |
Yes |
||
|
Cornwall |
Hannah Osborn |
Fully Executed |
Yes |
Performed |
|||
|
Nottingham |
Aloysious Aravinthan |
Fully Executed |
Yes |
Performed |
Yes |
||
|
Basingstoke |
Kamran Ala |
Fully Executed |
Yes |
Performed |
|||
|
East Kent |
Jayshri Shah |
Fully Executed |
Yes |
Booked |
|||
|
Portsmouth |
Richard Aspinall |
Awaiting Site Signature |
Performed |
||||
|
Bristol - Weston |
PI James Orr Sub-I Andrew Bell |
Fully Executed |
Yes |
Booked Arranging |
|||
|
Liverpool |
Tim Cross |
With local R&D |
Arranging |
||||
|
Aintree |
Nick Stern |
With local R&D |
Arranging |
||||
|
Sheffield |
Laura Harrison |
With local R&D |
|||||
|
Royal London |
Janet Dearden |
With local R&D |
|||||
|
Royal Free |
Aileen Marshall |
With local R&D |
|||||
|
Birmingham |
Tahir Shah |
With local R&D |
|||||
|
Guys and St Thomas' |
Bo Wang |
With local R&D |
|||||
|
Southampton |
Mark Wright |
With local R&D |
|||||
|
Bournemouth |
Safa Al-Shamma |
With local R&D |
|||||
|
Derby |
Andrew Austin |
TBD |
|||||
|
Gloucester |
Coral Hollywood |
TBD |
|||||
|
Leicester |
Ka-Kit Li |
TBD |
|||||
|
Newcastle |
Stuart McPherson |
TBD |
|||||
|
Manchester |
?Martin Prince |
TBD |
|||||
|
Cambridge |
Mike Allison |
TBD |
|||||
|
Basildon |
TBD |
||||||
|
Royal Devon |
TBD |
||||||
|
Whittington Health |
TBD |
||||||
|
Total Patients Recruited |
85 |
Best Wishes,
Ellie, Will, Jenni, Andy and James