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The 1st DeLIVER Newsletter

Dear study teams,

We are delighted to update you with the first PEARL STUDY newsletter — and will now provide an update to all every couple of weeks now that recruitment has started. It has been a pleasure to meet many of you during the SIVs in recent weeks. The new DeLIVER website is now up and running to we will also post news and updates here: https://deliver.cancer.ox.ac.uk/

 

We do recognise that the resource situation is still challenging with staff members currently unwell due to the latest COVID wave (and/or exhausted following an incredibly intense couple of years), so Will, Jenni and I would like to extend a huge thank you to all of you for your support in getting the study underway.

 

As you know, PEARL is the first major prospective trial that aims to develop new biomarkers for HCC early detection in patients with liver cirrhosis — and recruitment at speed really is now an imperative for the study as several years follow up is required to meet the study end points. Andy and James have managed to link the REDCAP database to a bioanalysis portal that can look at recruitment and analyse the data real time, and so we can provide some of this as the study progresses which we hope that you will find stimulating (see graph below). We will also provide a snapshot of site set up progress (see table below), that eventually, once all “green” will change to numbers recruited. We are really on standby now to make the study as easy as possible to recruit to, and welcome feedback in real time of any issues re the study protocol, blood sampling or shipment of samples and we will aim to fix these rapidly.

 

We would also like to take this opportunity to invite you to a Face to Face study day Wednesday June 8th in Oxford -PIs, nurses and other key staff all welcome. Please do save the date (with more details to follow). We will reimburse reasonable travel costs and provide a nice lunch!

 

May we also take this opportunity to congratulate Lynsey Corless on her new position as CRN national hepatology specialty lead (clearly leading by example as Hull is the first site, outside Oxford, to recruit to PEARL!)

 

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

Oxford

Ellie Barnes

Fully Executed

Yes

Performed

Yes

23/02/2022

Hull

Lynsey Corless

Fully Executed

Yes

Performed

Yes

24/03/2022

Kings

Kosh Agarwal

Fully Executed

Yes

Performed

Yes

Wycombe

James Maggs

Fully Executed

Yes

Performed

Yes

Brighton

Sumita Verma

Fully Executed

Yes

Performed

Yes

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

Bradford

Sulleman Moreea

Fully Executed

Yes

Performed

Yes

C&W

Matthew Foxton

Fully Executed

Yes

Performed

Awaiting supplies

St George's

Dan Forton

Fully Executed

Yes

Performed

Nottingham

Steve Ryder

Fully Executed

Yes

Performed

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Leeds

Ian Rowe

Fully Executed

Performed

Middlesbrough

Darren Craig

Fully Executed

Yes

Booked

County Durham & Darlington

Francisco Porras Perez

Fully Executed

Yes

Performed

Imperial

Nowlan Selvapatt

Fully Executed

Yes

Arranging

Cornwall

Zoe Berry

Fully Executed

Yes

Arranging

Portsmouth

Richard Aspinall

With local R&D

Booked

Liverpool

Tim Cross

With local R&D

Sheffield

Laura Harrison

With local R&D

Bristol

James Orr

With local R&D

East Kent

Jayshri Shah

With local R&D

Royal London

Janet Dearden

With local R&D

Royal Free

Aileen Marshall

With local R&D

Basingstoke

Kamran Ala

With local R&D

Birmingham

Tahir Shah

With local R&D

Derby

Andrew Austin

With local R&D

Gloucester

Coral Hollywood

TBD

Leicester

Ka-Kit Li

TBD

Southampton

Mark Wright

TBD

Guys and St Thomas'

Bo Wang

TBD

Newcastle

Stuart McPherson

TBD

Manchester

?Martin Prince

TBD

Cambridge

Mike Allison

TBD

Milton Keynes

TBD

Basildon

Chirag Oza

TBD

Bournemouth

TBD

 

PEARL recruitment 1

 

 

Best Wishes

Ellie, Jenni, Will, Andy and James