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The 6th DeLIVER Newsletter

Dear study teams, 

 

This is our 6th newsletter to update on site recruitment and progress. Delighted that we are now at 367 patients for PEARL and 15 patients for SELINA, with underlying disease aetiology distributed as expected-still a way to go meet the targets of 3000 and 100+ respectively -but firmly underway. The tables extracted last week below demonstrate the extraordinary commitment of UK hepatology and we are truly proud to be in this community.

Oxford, Plymouth, Kings, Chelsea and Westminster and Middlesborough are leading the charge for PEARL but others also recruiting significant numbers (Aintree). Royal Free, Leeds and Plymouth have recently started recruitment to SeLINA-adding to those recruited by Emma and the team at Oxford.

We sent a small gift of appreciation to Middlesbrough (Julie and Leanne in the photo -shared with permission!) and Bradford- for pushing on through August and over recruiting…these are our  ‘Sites of the Summer 2022’ 😊.

 

Hamper 6

 

PEARL

 

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

No. Patients Recruited

Oxford

Emma Culver

Fully Executed

Yes

Performed

Yes

23/02/2022

60

Hull

Lynsey Corless

Fully Executed

Yes

Performed

Yes

24/03/2022

15

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

13/04/2022

26

St George's

Dan Forton

Fully Executed

Yes

Performed

Yes

26/04/2022

16

Kings

Kosh Agarwal

Fully Executed

Yes

Performed

Yes

29/04/2022

35

Bradford

Sulleman Moreea

Fully Executed

Yes

Performed

Yes

11/05/2022

12

C&W

- West Middlesex

Matthew Foxton

Fully Executed

Yes

Performed

Yes

11/05/2022

20/09/2022

33

2

Brighton

Sumita Verma

Fully Executed

Yes

Performed

Yes

13/05/2022

7

Middlesbrough

Darren Craig

Fully Executed

Yes

Performed

Yes

26/05/2022

37

Imperial

Nowlan Selvapatt

Fully Executed

Yes

Performed

Yes

30/05/2022

15

Leeds

Ian Rowe

Fully Executed

Yes

Performed

Yes

06/06/2022

3

Nottingham

Aloysious Aravinthan

Fully Executed

Yes

Performed

Yes

07/07/2022

17

Wycombe

James Maggs

Fully Executed

Yes

Performed

Yes

11/07/2022

7

Basingstoke

Kamran Ala

Fully Executed

Yes

Performed

Yes

21/07/2022

2

Liverpool

Tim Cross

Fully Executed

Yes

Performed

Yes

22/07/2022

12

Portsmouth

Richard Aspinall

Fully Executed

Yes

Performed

Yes

28/07/2022

7

Co. Durham & Darlington

Francisco Porras Perez

Fully Executed

Yes

Performed

Yes

01/08/2022

5

Aintree

Nick Stern

Fully Executed

Yes

Performed

Yes

16/08/2022

19

Bristol

- Weston

PI Gau Appanna

Sub-I Andrew Bell

Fully Executed

Yes

Performed 

Yes

06/09/2022

 

4

Bournemouth

Safa Al-Shamma

Fully Executed

Yes

Performed

Yes

12/09/2022

5

Royal Free

Aileen Marshall

Fully Executed

Yes

Performed

Yes

14/09/2022

3

Southampton

Mark Wright

Fully Executed

Yes

Performed

Yes

22/09/2022

4

Birmingham

Tahir Shah

Fully Executed

Yes

Performed

Yes

10/10/2022

1

East Kent

Jayshri Shah

Fully Executed

Yes

Performed

Yes

13/10/2022

2

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Yes

 

Cornwall

Keely Lane

Fully Executed

Yes

Performed

 

 

 

Royal London

Janet Dearden

Fully Executed

Yes

Booked

 

 

 

Derby

- Burton

Andrew Austin

Fully Executed

Yes

Performed

 

 

 

Guys and St Thomas'

Bo Wang

Fully Executed

      Yes

 

 

 

 

Newcastle

Stuart McPherson

With local R&D

 

 

 

 

 

Royal Devon

Christina Levick

With local R&D

 

Booked

 

 

 

Sheffield

Laura Harrison

With local R&D

 

 

 

 

 

Leicester

Ka-Kit Li

With local R&D

 

 

 

 

 

Gloucester

Coral Hollywood

With local R&D

 

      Booked

 

 

 

Manchester

Martin Prince

With local R&D

 

Cambridge

Mike Allison

TBD

 

Total Patients Recruited

 

 

 

 

 

 

349

 

PEARL recruitment 6

 

SELINA

 

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

No. Patients Recruited

Oxford

Emma Culver

Fully Executed

Yes

Performed

Yes

23/05/2022

8

Leeds

Ian Rowe

Fully Executed

Yes

Performed

Yes

27/07/2022

2

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

16/08/2022

2

Royal Free

Aileen Marshall

Fully Executed

Yes

Performed

Yes

03/10/2022

3

Nottingham

Guru Aithal

Fully Executed

Yes

Performed

Yes

 

 

Birmingham

Tahir Shah

Fully Executed

Yes

Performed

Yes

 

 

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Yes

 

 

St George's

Dan Forton

With local R&D

 

 

 

 

 

Bournemouth

Jo Tod

Fully Executed

Yes

Arranging

 

 

 

Southampton

Janisha Patel

With local R&D

 

 

 

 

 

Liverpool

Tim Cross

Awaiting signature

 

Performed

 

 

 

Aintree

Nick Stern

 

Performed

 

 

 

Royal London

Janet Dearden

With local R&D

 

Booked

 

 

 

Newcastle

Helen Reeves

With local R&D

 

 

 

 

 

Royal Devon

Christina Levick

With local R&D

 

 

 

 

 

Cambridge

 

With local R&D

 

 

 

 

 

Total Patients Recruited

 

 

 

 

 

 

15

 

SELINA recruitment 6

 

Now that we are making significant progress in recruitment, we hope to establish the Trial Steering Committee that will meet every 3 months to progress science -and we will keep you all in the loop with this too of course.

Just to say that we are staying open throughout Christmas this year -so please don’t hold back for us! Do drop us a line if you have any queries -we are on standby at all times to help and support. May I take this opportunity to introduce Emily (Ashwin). Emily was recently working in the lab at Oxford but has now taken on the project management/coordination role for the SELINA study in addition.

 

A heartfelt thanks for all the effort over recent months…….

Best Wishes

Ellie, Will, Jenni, Emily, Andy and James