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The 3rd DeLIVER Newsletter

Dear study teams,

 

This is our third PEARL STUDY newsletter. Below is the latest “data” extracted from the bioanalysis portal today (excluding 3 patients that have been recruited this afternoon)!

 

Congratulations to the teams at Plymouth (Matthew C) and Georges (Dan F), Hull (Lyndsey C), Oxford (Emma C) and Kings (KoshA) for ongoing recruitment. And to Bradford (Sulleman M), C&W (Matthew F) and Brighton (Sumita V) now off to a flying start: Now 57 patients towards our 3000 patient target.

Interesting to see the even spread of NAFLD, HCV and Alcoholic liver disease-with one Haemochromatosis patient creeping in.

 Aetiology 3

Some of us attended HCC-UK this time last week at Kings-it was a great meeting that really outlined the need to detect HCC early, to improve HCC screening protocols, and to better assess some of the existing HCC biomarker scores (e.g. GALAD) in prognostic studies- as well as showing some great basic science. We really hope that PEARL will contribute to these aims.

 

We are really looking forward to meeting you at our Face-to-Face study day Wednesday June 8th in Oxford -PIs, nurses and other key staff all welcome. The program is really coming together (thanks Francoise), are we are looking forward to meeting the nursing teams (who we know really do the hard work!). Do drop Jenni B a line if for some reason you do not have the link/invite to sign up.

 

We remain on standby to make the study as easy as possible to recruit to, and welcome feedback in real time of any issues regarding the study protocol, blood sampling or shipment of samples — very keen to make this as easy as possible to recruit to.

 

Site

PI

mNCA Status

C&C Approved

SIV

Green Light Issued

First Patient Recruited

No. Patients Recruited

Oxford

Emma Culver

Fully Executed

Yes

Performed

Yes

23/02/2022

19

Hull

Lynsey Corless

Fully Executed

Yes

Performed

Yes

24/03/2022

6

Plymouth

Matthew Cramp

Fully Executed

Yes

Performed

Yes

13/04/2022

10

St George's

Dan Forton

Fully Executed

Yes

Performed

Yes

26/04/2022

6

Kings

Kosh Agarwal

Fully Executed

Yes

Performed

Yes

29/04/2022

5

Bradford

Sulleman Moreea

Fully Executed

Yes

Performed

Yes

11/05/2022

4

C&W

Matthew Foxton

Fully Executed

Yes

Performed

Yes

11/05/2022

3

Brighton

Sumita Verma

Fully Executed

Yes

Performed

Yes

13/05/2022

1

Wycombe

James Maggs

Fully Executed

Yes

Performed

Yes

NNUH

Simon Rushbrook

Fully Executed

Yes

Performed

Yes

Leeds

Ian Rowe

Fully Executed

Yes

Performed

Yes

Middlesbrough

Darren Craig

Fully Executed

Yes

Performed

Yes

Imperial

Nowlan Selvapatt

Fully Executed

Yes

Performed

Yes

County Durham & Darlington

Francisco Porras Perez

Fully Executed

Yes

Performed

Cornwall

Hannah Osborn

Fully Executed

Yes

Performed

Nottingham

TBD

Fully Executed

Yes

Performed

Basingstoke

Kamran Ala

Fully Executed

Yes

Performed

East Kent

Jayshri Shah

Fully Executed

Yes

Arranging

Portsmouth

Richard Aspinall

Awaiting Sponsor Signature

Performed

Liverpool

Tim Cross

With local R&D

Sheffield

Laura Harrison

With local R&D

Bristol

James Orr

With local R&D

Royal London

Janet Dearden

With local R&D

Royal Free

Aileen Marshall

With local R&D

Birmingham

Tahir Shah

With local R&D

Guys and St Thomas'

Bo Wang

With local R&D

Southampton

Mark Wright

With local R&D

Bournemouth

Safa Al-Shamma

With local R&D

Derby

Andrew Austin

TBD

Gloucester

Coral Hollywood

TBD

Leicester

Ka-Kit Li

TBD

Newcastle

Stuart McPherson

TBD

Manchester

?Martin Prince

TBD

Cambridge

Mike Allison

TBD

Basildon

TBD

Royal Devon

TBD

Whittington Health

TBD

Total Patients Recruited

54

 

 

PEARL recruitment 3

Best Wishes and a happy weekend,

Ellie, Will, Jenni, Andy and James