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Development of HCC early detection patient cohorts (Work package 1) consists of three ethically approved research studies that recruit cirrhosis and/or HCC patient groups in order to address different aspects of early HCC development. They will do this by characterising the cirrhotic liver in patients with and without HCC through liver biopsy, surgery and fine needle aspiration (DELPHI study, N=60 participants), by identifying biomarkers in urine, blood and liver tissue as well as from liver imaging which are associated with early development of HCC (SELiNa study, N=250 participants) and by evaluating the risk factors and identifying predictive biomarker for the development of HCC longer-term (Pearl study, N=3000 participants).