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Work Package 3

Microenvironmental determinants of malignant transformation (Work package 3) will define the microenvironmental determinants that drive malignant transformation by characterising the phenotype of cancer and non-cancer cells using transcriptomic analysis, single-copy RNA sequencing (scRNA-seq), TET-assisted pyridine borane sequencing (TAPS) and for the mapping of proteins/metabolomes in order to identify pre-cancerous HCC signatures.